One drug comes out top in a large analysis , external of how effective antidepressants are at keeping patients free of symptoms of depression. Escitalopram performed best at preventing patients from relapsing in a study involving nearly 10,000 people prescribed different medications for up to a year. Two other pills - agomelatine and duloxetine - came next, while prozac (also known as fluoxetine) ranked just below them. Experts stress the findings don't mean that everyone with severe depression should switch to escitalopram, or that other antidepressants aren't any good, because all the drugs can work and each has its pros and cons. Depression is common, affecting around one in six people in the UK.
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